Yes, you can apply for Indefinite Leave to Remain (ILR) in the UK once you have held this visa for 5 years and can use time spent on the Tier 2 General visa immediately prior to the Skilled Worker visa towards this 5 years.
There are other eligibility requirements for ILR which you should be mindful of. Please contact us to discuss these to ensure that you do not fall foul of these whilst holding your visa.